Pain Relief Medications Ultram Ultram is a non-opioid prescription pain relief medication that is meant to help alleviate moderate to moderately severe pain. Ultram is a synthetic analgesic, not an anti-inflammatory, which means that people who cannot take anti-inflammatories do to their side effects, can often take Ultram to help relieve their pain. Fioricet Fioricet is a combination of Acetaminophen, Butalbital, and Caffeine. Acetaminophen is a pain reliever and fever reducer. Butalbital is in a class of drugs called barbiturates that slow down your central nervous system (brain and nerve impulses) causing relaxation. Caffeine is believed to constrict dilated blood vessels that may contribute to tension headaches. Together, acetaminophen, butalbital, and caffeine are used to relieve complex tension (muscle contraction) headaches although precisely how it works is unknown. Tramadol Tramadol is a non-opioid prescription pain relief medication that is meant to help alleviate moderate to moderately severe pain. Tramadol is a synthetic analgesic, not an anti-inflammatory, which means that people who cannot take anti-inflammatories do to their side effects, can often take Tramadol to help relieve their pain. Tramadol is the generic of the prescription drug Ultram Imitrex Imitrex is used to treat migraine headache attacks once they occur. Imitrex is not effective in preventing migraines. Imitrex is not to be used for other types of headaches. Ultracet Ultracet is a unique pain medication that combines tramadol, a leading prescription pain reliever, and acetaminophen, the most commonly recommended over-the-counter analgesic in the U.S. Ultracet has been approved for the short-term (five days or less) management of acute pain. Ultracet provides powerful relief from many kinds of acute pain, including joint pain, strains and sprains, post-operative recuperation, joint pain flares (i.e., associated with osteoarthritis) and muscle aches. Esgic Plus Esgic Plus is a barbiturate sedative (butalbital) mixed with a non-aspirin pain medication (acetaminophen) and caffeine. This non-narcotic pain medication and relaxant is often prescribed for tension headaches caused by contractions of the muscles in the neck and shoulder area, and migraines. Acetaminophen is a pain reliever and fever reducer. Butalbital is in a class of drugs called barbiturates that slow down your central nervous system (brain and nerve impulses) causing relaxation. Caffeine is believed to constrict dilated blood vessels that may contribute to tension headaches.